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KMID : 0371219920140010148
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Medical Bulletin of the Presbyterian Medical Center
1992 Volume.14 No. 1 p.148 ~ p.160
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Experimental Study for the Nerve Regeneration Potential with Silicone Tube
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Abstract
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Seventy-five sciatic nerves of New Zealand white rabbit were divided into 5 groups direct apposition(no gap), 5mm, 10mm, 15mm and 20mm gap were used. And group were subdivided into A(no other treatment), B(topical steroid), C group(end-to-end
anastomosis silicone tube).
At 3, 6, 12 weeks, nerve conduction velocity, gross observation, light and electron microscopic observation were done.
The successful regeneration of a multifascicular peripheral nerv through a silicone tube across a gap of 15 mm in the rabbit sciatic nerve was observed. The importance of the distal nerve as a source of traget-derived neuronotrophic factors
necessary
for the successful regeneration of the proximal regeneration nerve is emphasized.
A simplified research model for further investigation into and manipulation of the biological processes of nerve regenration is mandatory. The potential clinleal utilization of silicone tube in the management of peripheral nerve injuries required
further study.
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KEYWORD
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